Showing metabocard for PC(18:2(9Z,12Z)/18:2(9Z,12Z)) (BMDB0008138)

IdentificationTaxonomyPhysical propertiesSpectraConcentrationsLinksReferencesXML
Record Information
Version1.0
Creation Date2016-10-03 17:14:36 UTC
Update Date2020-06-04 19:46:17 UTC
MCDB ID BMDB0008138
Secondary Accession Numbers
  • BMDB08138
Metabolite Identification
Common NamePC(18:2(9Z,12Z)/18:2(9Z,12Z))
DescriptionPC(18:2(9Z,12Z)/18:2(9Z,12Z)), also known as L-dilinoleoyllecithin or dilinoleoylphosphatidylcholine, belongs to the class of organic compounds known as phosphatidylcholines. These are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage. Thus, PC(18:2(9Z,12Z)/18:2(9Z,12Z)) is considered to be a glycerophosphocholine lipid molecule. PC(18:2(9Z,12Z)/18:2(9Z,12Z)) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. PC(18:2(9Z,12Z)/18:2(9Z,12Z)) exists in all eukaryotes, ranging from yeast to humans. PC(18:2(9Z,12Z)/18:2(9Z,12Z)) participates in a number of enzymatic reactions, within cattle. In particular, S-Adenosylhomocysteine and PC(18:2(9Z,12Z)/18:2(9Z,12Z)) can be biosynthesized from S-adenosylmethionine and pe-nme2(18:2(9Z,12Z)/18:2(9Z,12Z)) through its interaction with the enzyme phosphatidylethanolamine N-methyltransferase. Furthermore, Cytidine monophosphate and PC(18:2(9Z,12Z)/18:2(9Z,12Z)) can be biosynthesized from CDP-choline and DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0); which is mediated by the enzyme choline/ethanolaminephosphotransferase. Finally, PC(18:2(9Z,12Z)/18:2(9Z,12Z)) and L-serine can be converted into choline and PS(18:2(9Z,12Z)/18:2(9Z,12Z)) through its interaction with the enzyme phosphatidylserine synthase. In cattle, PC(18:2(9Z,12Z)/18:2(9Z,12Z)) is involved in a couple of metabolic pathways, which include phosphatidylcholine biosynthesis PC(18:2(9Z,12Z)/18:2(9Z,12Z)) pathway and phosphatidylethanolamine biosynthesis pe(18:2(9Z,12Z)/18:2(9Z,12Z)) pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
(2R)-2,3-Bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl 2-(trimethylammonio)ethyl phosphateChEBI
(2R)-2,3-Bis{[(9Z,12Z)-octadeca-9,12-dienoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphateChEBI
1,2-Di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineChEBI
1,2-Di-O-linoleoyl-sn-glycero-3-phosphocholineChEBI
1,2-Dilinoleoyl-sn-glycero-3-phosphocholineChEBI
DI-linoleoyl-3-sn-phosphatidylcholineChEBI
DilinoleoylphosphatidylcholineChEBI
DL-PCChEBI
DLNPCChEBI
DLPCChEBI
GPCho(18:2/18:2)ChEBI
GPCho(18:2n6/18:2n6)ChEBI
GPCho(18:2W6/18:2W6)ChEBI
L-DilinoleoyllecithinChEBI
PC(18:2/18:2)ChEBI
PC(18:2n6/18:2n6)ChEBI
PC(18:2W6/18:2W6)ChEBI
Phosphatidylcholine(18:2/18:2)ChEBI
Phosphatidylcholine(18:2n6/18:2n6)ChEBI
Phosphatidylcholine(18:2W6/18:2W6)ChEBI
(2R)-2,3-Bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl 2-(trimethylammonio)ethyl phosphoric acidGenerator
(2R)-2,3-Bis{[(9Z,12Z)-octadeca-9,12-dienoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphoric acidGenerator
1,2-Linoleoylphosphatidylcholine, 14C-labeled CPD, (R-(all Z))-isomerHMDB
1,2-Dilinoleoyl-3-glycerophosphocholineHMDB
1,2-LinoleoylphosphatidylcholineHMDB
DLPC LipidHMDB
DilinoleoyllecithinHMDB
Dilinoleoyl phosphatidylcholineHMDB
1,2-Linoleoyl-sn-glycero-3-phosphocholineHMDB
1,2-Linoleoylphosphatidylcholine, (R-(all Z))-isomerHMDB
Phosphatidylcholine(36:4)HMDB
LecithinHMDB
PC(36:4)HMDB
1,2-Dilinoleoyl-rac-glycero-3-phosphocholineHMDB
1,2-Di(9Z,12Z-octadecadienoyl)-rac-glycero-3-phosphocholineHMDB
GPCho(36:4)HMDB
1,2-Dilinoleoyl-GPCHMDB
PC(18:2(9Z,12Z)/18:2(9Z,12Z))Lipid Annotator
Chemical FormulaC44H80NO8P
Average Molecular Weight782.0817
Monoisotopic Molecular Weight781.562155053
IUPAC Name(2-{[(2R)-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium
Traditional Name(2-{[(2R)-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium
CAS Registry Number998-06-1
SMILES
CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC
InChI Identifier
InChI=1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h14-17,20-23,42H,6-13,18-19,24-41H2,1-5H3/b16-14-,17-15-,22-20-,23-21-/t42-/m1/s1
InChI KeyFVXDQWZBHIXIEJ-LNDKUQBDSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as phosphatidylcholines. These are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphocholines
Direct ParentPhosphatidylcholines
Alternative Parents
Substituents
  • Diacylglycero-3-phosphocholine
  • Phosphocholine
  • Fatty acid ester
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • Quaternary ammonium salt
  • Tetraalkylammonium salt
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Organopnictogen compound
  • Amine
  • Organic salt
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP5.68ALOGPS
logP8.44ChemAxon
logS-7.4ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area111.19 ŲChemAxon
Rotatable Bond Count40ChemAxon
Refractivity238.74 m³·mol⁻¹ChemAxon
Polarizability93.58 ųChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 21V, positivesplash10-001i-0000000900-bd3ed2ff47d70cb5ac3e2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 32V, positivesplash10-001i-0400000900-d002062176d9e1a58fcc2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 43V, positivesplash10-001i-0900000100-1d81bafed34be0680f8b2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 54V, positivesplash10-001i-0900000000-b42fac72a675be84234d2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 65V, positivesplash10-001i-0900000000-a1756c5f56f420105ec62020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 76V, positivesplash10-001i-0900000000-57ce459f0f2b4ef3b3882020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 87V, positivesplash10-001i-1900000000-26d27e14f475fd58e1012020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 98V, positivesplash10-001i-2900000000-ee4e32911559ac08e5692020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 109V, positivesplash10-001i-3900000000-c96a527426c6410636622020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 131V, positivesplash10-003i-7900000000-8fd87469bebc7841cfeb2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 164V, positivesplash10-002s-9700000000-805c2bda88ecbe7681342020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 196V, positivesplash10-002k-9500000000-739389c73c5b7af69f2b2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 240V, positivesplash10-0002-9200000000-d6507de242e2b9f691192020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 286V, positivesplash10-0002-9000000000-747c2f7f10ab5dc686cb2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - Orbitrap 351V, positivesplash10-0002-9000000000-e963880e5dd642c7c9672020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - n/a 54V, positivesplash10-0fe0-0000090600-6c4096785e931bdd859a2020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - n/a 54V, positivesplash10-0006-0000900000-d438f5570e710ae02ee62020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - n/a 54V, positivesplash10-08fr-0934000000-a2858d3a6aed2e8631802020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - n/a 54V, positivesplash10-0udi-0300090000-e353c4c82a0a4a7c7e362020-07-22View Spectrum
LC-MS/MSLC-MS/MS Spectrum - n/a 54V, positivesplash10-000i-9200000000-b6ca8b900ee76df8ea582020-07-22View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0000000900-95a10c93ea7d71892a442017-10-04View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-0600000900-da1f205f6fe8475ad9ed2017-10-04View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-1900030300-707d383caeedd787dae62017-10-04View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-0000000900-2534b1e8e0eb889fbec22021-09-22View Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-003r-0080020900-5688f54205e1eea312ab2021-09-22View Spectrum
Concentrations
StatusValueReferenceDetails
Detected and Quantified1.20 +/- 0.02 uM details
Detected and Quantified1.63 +/- 0.04 uM details
Detected and Quantified1.86 +/- 0.03 uM details
Detected and Quantified1.06 +/- 0.01 uM details
HMDB IDHMDB0008138
DrugBank IDDB04372
Phenol Explorer Compound IDNot Available
FoodDB IDFDB030223
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound5288075
PDB IDNot Available
ChEBI ID42027
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. A. Foroutan et al. (2019). A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation). Journal of Agricultural and Food Chemistry.